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4 Best Probiotics for Leaky Gut

best probiotic for leaky gut

The leaky gut syndrome is caused by undigested proteins and bad bacteria leaking into our bloodstream, eliciting an immune reaction. 

This can result in widespread systemic inflammation, leading to numerous health problems like chronic fatigue, eczema, Irritable Bowel Syndrome(IBS), depression, anxiety, and a lowered ability to digest food with decreased absorption of nutrients. 

I’m not sure if I got leaky gut syndrome since it’s hard to test and confirm it. However, I had symptoms such as bad skin, IBS, and depression, all associated with the abovementioned disorder.

With the symptoms getting quite uncomfortable and difficult to deal with, I switched to probiotic supplementations. And I might say it was one of the best decisions. With probiotics, I felt much better and healthier. 

Here are the top 5 probiotics for the leaky gut syndrome, in my opinion.

BEST Probiotics for Leaky Gut Reviewed


This premium quality probiotic offered by SEED ensures your gastrointestinal health and makes sure to keep inflammatory conditions such as gastritis at bay. 

These ALL-in-ONE probiotic capsules are formulated with 24 clinically tested specific strains and ingredients. Some of them beneficial for GUT health are Bifidobacterium longum, Bifidobacterium breve, Lactiplantibacillus plantarum. Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium lactis, Lactobacillus crispatus, Lacticaseibacillus casei. 

All the strains work synergistically to strengthen your gut immune function, allow micronutrient synthesis in your body, and strengthen your GUT immunity. The daily Gut Barrier Integrity Probiotic Blend comprises 37.0 billion AFU for gastrointestinal health. 

With so much consideration by the scientists of SEED, the daily synbiotic is formulated by considering the Vegans. Not only this, it is gluten-free, dairy-free, soy-free, and much more, with zero preservatives added! 

Besides, the product is made with a precise amalgamation of the outer Prebiotic capsule and inner Probiotic capsule. Thus, when you are ordering again, all you need to do is order sustainable refills. 

Read the Full Review

  • 100% Vegan
  • Free of Allergens and Preservatives
  • Contains 53.6 Billion AFU
  • Requires subscription
  • Proprietary formula
  • May experience gastrointestinal sensitivity

Daily Balance 2-in-1 Prebiotics & Probiotics by RenewLife

Renew Life is believed to sell more than 40 probiotic-based products designed following multiple requirements. For example, the products can be chosen based on the category, such as targeted probiotics, to-go probiotics, and essential probiotics. 

One of the most potent and well-known probiotic blends by Renew life includes Daily Balance 2-in-1 Prebiotics & Probiotics. This 8.9 Billion CFU with more than 10 clinically tested probiotics strains are aimed to enhance gut health by helping ease occasional digestive upsetness, rebalance your gut motility and assist in immune and respiratory health. 

Strains such as rhamnosus GG, B. lactis Bi-07, B. lactis HN019, L. acidophilus NCFM®, L. paracasei Lpc-37® can be found in increased quantities in the Daily Balance. These strains promote digestive balance and regularity, keeping and maintaining a healthy gut lining. 

These clinically-tested probiotic strains come in a uniquely designed delayed-release, once-daily capsule. 

Daily Balance 2-in-1 Prebiotics & Probiotics by RenewLife
  • Available on other retailers as well, such as Amazon, Walmart, and Target
  • Increased CFU and multistrain
  • Due to the high culture count, it requires refrigeration

Athletic Green

AG1, a powdered supplement, is absorbed way better, having gentler effects on our gastrointestinal tract especially by regulating the intestinal lining intact alongside playing a dynamic role in the human body. 

The product contains approximately 75 different vitamins, minerals, and other ingredients from plant-based products. 

Interestingly, the attraction towards AG1 is the presence of prebiotics and probiotics, all earmarked for better and improved overall health and thus skin breakouts can also be avoided with this. It also aids in immunity, energy, and rapid recovery such as acne. 

For customer ease, you can order AG1 in three different ways. It can be ordered for a one-time purchase costing them $99. This serving lasts for 30 days. 

Their single subscription is, however, cheaper than the former, costing only $75. This includes 30 servings of AG1 in a single pouch. With this single subscription, you can have five free travel packs. 

Lastly, their double subscription, although costing $149, also has various advantages. The subscription includes 60 servings of AG1 in two pouches. You can also avail free vitamin D3+K and five travel packs. 

AG1 is free from gluten, egg, sugar, dairy, and nuts. This keeps the fear of contracting allergies at a minimum.  


Athletic Greens 1
  • Third-party tested for quality and purity 
  • Completely allergen free 
  • Designed especially for the entire human body functions
  • It can be expensive for many 
  • The label does not include the dose of each ingredient

Daily Probiotic by Persona

Persona offers some potent supplements aimed to strengthen your body. When it comes to your digestion, Persona’s Daily Probiotic is the one to opt for. 

This Daily Probiotic helps promote digestion, strengthen immunity and boost your mood as well. It assists in soothing the regular bloating and irregularities. Through this, your intestinal barrier remains unblemished and the leaky gut syndrome is far from occurring. 

The strains commonly found in Daily Probiotic include Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus salivarius, and Lactobacillus bulgaricus. A total of 3 billion CFU amount per serving is present in the product. 

Daily probiotic costs upto $0.54 per day with rapid and smooth delivery. 

The product is also free from all nuts, egg, fish, peanuts, wheat and soy. This makes sure that there are no possible allergic reactions. 

Daily Probiotic helps restore the gut microbiome back to its original flora since the microbial population plays an important role in maintaining the gut lining. 

  • Aligns your body and mood, thus regulating mood
  • Restores the natural microbiome of your gut
  • Flatulence and upset stomach in the beginning

What is a leaky gut syndrome, and is it real? 

Leaky gut syndrome, also known as intestinal hyperpermeability, has gained the attention of many people associated with medicine, especially natural health enthusiasts. However, there is a lot of controversy around this term, and some medical practitioners even deny the existence of this condition. 

Nonetheless, several other medical blogs and articles suggest that this condition might be the root cause of certain chronic gastrointestinal and systemic disorders. So what does leaky gut mean, and what causes it in the first place? 

Leaky gut syndrome/intestinal hyperpermeability is when your gut lining is disrupted, and several harmful substances like undigested food, bad bacteria, etc., can leak into your bloodstream. 

Your intestinal lining is made up of epithelial cells attached through tight junctions. These tight junctions make your gut lining semi-permeable and thus only allow specific substances to pass through. However, harmful substances can make their way to your bloodstream with a damaged gut wall, resulting in systemic inflammation and immune reactions. 

According to Healthline, zonulin, a protein, is the key regulator of intestinal permeability, and bacteria and gluten trigger its release. Nonetheless, other factors might also result in leaky gut syndrome. Such as: 

  • A diet rich in sugar
  • Prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) 
  • The deficiency of vitamin A and D, along with zinc, can also increase intestinal permeability
  • Inflammation and 
  • Dysbiosis, i.e., imbalance in gut microflora 

According to an article, the common symptoms to look for in leaky gut syndrome are 

Chronic diarrhea, gas, bloating, headaches, excessive fatigue, skin rashes such as acne and eczema, arthritis, etc.  

What diseases are associated with leaky gut syndrome? 

There’s a lot of contradiction correlated with the leaky gut syndrome and whether it is a cause or symptom of a disease. 

Nevertheless, leaky gut is associated with several other chronic diseases, and it’s worth mentioning them here and gaining more insight into this medical mystery. 

Celiac disease: This disorder results from increased sensitivity to gluten. As mentioned above, gluten triggers the release of zonulin, which increases intestinal permeability. 

Crohn’s disease: Increased intestinal permeability can result in persistent gut inflammation, characteristic of Crohn’s disease. 

Diabetes: A Lot of controversy lies with this disorder. Researchers suggest that the leaking of harmful substances resulting from a leaky gut can result in an immune reaction responsible for beta cell destruction in the pancreas, cells that release insulin. 

Other than the above-mentioned, disorders such as Irritable bowel syndrome, fibromyalgia, food allergies, and acne are also associated with leaky gut syndrome. 

Can probiotics be used with leaky gut syndrome? 

As mentioned above, it is believed that dysbiosis can be a cause that can lead to a leaky gut. An imbalance between good and bad bacteria in your gastrointestinal tract can worsen your gut problems and may lead to disrupted intestinal walls. 

It is hypothesized that modulating the gut microflora can help heal the gut’s disrupted and inflamed epithelial lining and help reduce intestinal permeability. 

According to Dr. Michael Ruscio, a holistic approach accompanied by probiotic supplementation can be a potential tool for leaky gut and alleviating its consequences. According to him, probiotics help restore the bacterial balance in your gut, simultaneously healing the intestinal lining and reducing inflammation. 

Several clinical evidence suggests that the intake of probiotics with multiple bacterial strains improved intestinal permeability. 

One such clinical study suggested that a 14-week-long supplementation with probiotics decreased zonulin production. A trial even suggested that Lactobacillus Rhamnosus showed beneficial effects on genes that regulated gut permeability.

Which probiotic blends are beneficial for leaky gut syndrome? 

It is often suggested to take a course of a multi-species probiotic blend for maximum benefit and maintenance of a healthy gut lining. However, it gets quite perplexing when deciding which ones can reverse intestinal hyperpermeability. 

Many clinical studies suggest that the best blend consisting of Lactobacillus and Bifidobacterium strains is the right option. 

These strains aid in a healthy inflammatory response and create a balanced bacterial flora in your gastrointestinal tract. 

Why is DS-01 Daily Synbiotic by SEED the Premium Probiotics to be used?

Probiotics offered by SEED are beneficial in almost every aspect of your body. SEED provides the best probiotic formula laden with multiple bacterial strains, whether your dermatological health or your cardiovascular system, to your gastrointestinal tract. 

Infection leading to diverticulitis and the associated consequences of the disease is predominantly related to your Gut. These can be managed with SEED’s 37.0 Billion AFU. It assists in your digestive health as well as your gut immunity. 

Probiotics offered by SEED are thoroughly tested and ensure that it doesn’t cause any adverse side effects. With its prebiotic capsule, one can have a more competent method of combating this disease. 

However, seed provides a premium-based formulation to its customers. Thus the product helps regulate the overall function of the human body instead of focusing on one single system.