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Best Probiotic for Histamine Intolerance

best probiotic for histamine intolerance

Histamine Intolerance is one terrible disorder. It makes you feel like there’s always someone standing around the corner waiting to punish you with a flare-up.

For me, these flare-ups were primarily red and dry eyelids. It took me years to figure out what went wrong with my body. A while later, when I learned what histamine intolerance is, I started researching the remedies that could help me avoid these symptoms. 

Like with all health problems, even histamine intolerance has its root in your gut. Due to an imbalance in your gut microflora, you might release excessive histamine, or your body isn’t able to degrade it.

So how do you get your gut bacteria back in balance? With probiotics, you’re in good hands. 

Let’s look at my 5 personal best probiotics for treating and reversing histamine intolerance. 

BEST Histamine Intolerance Probiotic


This premium quality probiotic offered by SEED ensures your gastrointestinal health and makes sure to keep inflammatory conditions such as gastritis at bay. 

These ALL-in-ONE probiotic capsules are formulated with 24 clinically tested specific strains and ingredients. Some of them beneficial for GUT health are Bifidobacterium longum, Bifidobacterium breve, Lactiplantibacillus plantarum. Lacticaseibacillus rhamnosus, Lacticaseibacillus rhamnosus, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium lactis, Lactobacillus crispatus, Lacticaseibacillus casei. 

All the strains work synergistically to strengthen your gut immune function, allow micronutrient synthesis in your body, and strengthen your GUT immunity. The daily Gut Barrier Integrity Probiotic Blend comprises 37.0 billion AFU for gastrointestinal health. 

With so much consideration by the scientists of SEED, the daily synbiotic is formulated by considering the Vegans. Not only this, it is gluten-free, dairy-free, soy-free, and much more, with zero preservatives added! 

Besides, the product is made with a precise amalgamation of the outer Prebiotic capsule and inner Probiotic capsule. Thus, when you are ordering again, all you need to do is order sustainable refills. 

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  • 100% Vegan
  • Free of Allergens and Preservatives
  • Contains 53.6 Billion AFU
  • Requires subscription
  • Proprietary formula
  • May experience gastrointestinal sensitivity

Ultimate care probiotic 150 billion by RenewLife

Renew Life is believed to sell more than 40 probiotic-based products designed following multiple requirements. For example, the products can be chosen based on the category, such as targeted probiotics, to-go probiotics, and essential probiotics. 

One of the most potent and well-known probiotic blends by Renew life includes Ultimate care probiotic 180 billion. This high CFU and multistrain probiotic is aimed to enhance gut health by helping ease occasional digestive upsetness, rebalance your gut motility and assist in keeping the normal gut flora. With that being said, excess histamine release is reduced. 

Strains such as rhamnosus GG, B. lactis Bi-07, B. lactis HN019, L. acidophilus NCFM®, L. paracasei Lpc-37® can be found in increased quantities in the Ultimate Care. These strains promote digestive balance and regularity, keeping common histamine intolerance disorders at bay. 

This 40-strain comprising blend can cost up to $52.49 per month. These clinically-tested probiotic strains come in a uniquely designed delayed-release, once-daily capsule.

Ultimate care probiotic 150 billion by RenewLife 
  • Available on other retailers as well, such as Amazon, Walmart, and Target
  • Increased CFU and multistrain
  • Due to the high culture count, it requires refrigeration

Athletic Green

AG1, a powdered supplement, is absorbed way better, having gentler effects on our gastrointestinal tract especially by regulating the intestinal lining intact alongside playing a dynamic role in the human body. 

The product contains approximately 75 different vitamins, minerals, and other ingredients from plant-based products. 

Interestingly, the attraction towards AG1 is the presence of prebiotics and probiotics, all earmarked for better and improved overall health and thus skin breakouts can also be avoided with this. It also aids in immunity, energy, and rapid recovery such as acne. 

For customer ease, you can order AG1 in three different ways. It can be ordered for a one-time purchase costing them $99. This serving lasts for 30 days. 

Their single subscription is, however, cheaper than the former, costing only $75. This includes 30 servings of AG1 in a single pouch. With this single subscription, you can have five free travel packs. 

Lastly, their double subscription, although costing $149, also has various advantages. The subscription includes 60 servings of AG1 in two pouches. You can also avail free vitamin D3+K and five travel packs. 

AG1 is free from gluten, egg, sugar, dairy, and nuts. This keeps the fear of contracting allergies at a minimum.  


Athletic Greens 1
  • Third-party tested for quality and purity 
  • Completely allergen free 
  • Designed especially for the entire human body functions
  • It can be expensive for many 
  • The label does not include the dose of each ingredient

Daily Probiotic by Persona

Persona offers some potent supplements aimed to strengthen your body. When it comes to your digestion, Persona’s Daily Probiotic is the one to opt for. 

This Daily Probiotic helps promote digestion, strengthen immunity and boost your mood as well. It assists in soothing the regular bloating and irregularities. Through this, your intestinal barrier remains unblemished and the leaky gut syndrome is far from occurring. 

The strains commonly found in Daily Probiotic include Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus salivarius, and Lactobacillus bulgaricus. A total of 3 billion CFU amount per serving is present in the product. 

Daily probiotic costs up to $0.54 per day with rapid and smooth delivery. 

The product is also free from all nuts, eggs, fish, peanuts, wheat, and soy. This makes sure that there are no possible allergic reactions. 

Daily Probiotic helps restore the gut microbiome back to its original flora since the microbial population plays an important role in maintaining the gut lining. 

  • Aligns your body and mood, thus regulating mood
  • Restores the natural microbiome of your gut
  • Flatulence and upset stomach in the beginning

What is Histamine intolerance, and how does it occur? 

Before we dive into details about which strains of probiotics are beneficial for people with histamine intolerance, it would make more sense to understand what this disorder is and how it occurs in the first place. 

Histamine is a chemical mediator that plays a potent role in your immune system. It takes part in many different processes in your body. However, its role in causing inflammation is the major one. It helps in vasodilation, bronchoconstriction, and even in the production of gastric acid. 

According to a very extensive article published by the American journal of clinical nutrition, histamine tolerance is the accumulation of an increased quantity of histamine in your body or an inability to metabolize it efficiently.

Ingesting an increased quantity of food rich in histamine such as fermented products, spinach, alcohol, shellfish, aged cheese can all cause a rise in your histamine levels and lead to histamine intolerance. Another cause behind this disorder is the impaired metabolization of histamine by diamine oxidase (DAO). 

According to optibac probiotics, besides the abovementioned causes, a disbalance in your gut microflora may also play a key role in histamine intolerance. 

An increased proportion of histamine may cause a wide range of symptoms mimicking an allergic reaction. The most common ones are headaches, congestion of the nose, wheezing, flushing, and urticaria. 

Can an imbalance in gut flora lead to histamine intolerance? 

Evidence from an article published by the journal of immunology suggests that gastrointestinal infections and the overgrowth of certain gram-negative bacteria like Escherichia coli and Salmonella typhimurium can lead to excessive histamine. 

A damaged gut can be a hub to several other disorders and may also reduce the likelihood of the DAO enzyme working efficiently. 

Sustained gastrointestinal health with a balanced microflora can be a potential step to regulate your histamine levels and avoid all the nasty symptoms that accompany it. 

Can probiotics be used in alleviating histamine intolerance?

Probiotics are supplements used to restore the good bacteria in your gut and reduce the bad ones. It helps keep your gut microbiome in balance and aids in maintaining your stomach lining. 

As mentioned above, a disbalance in your gut microflora or increased intestinal permeability can result in histamine intolerance, then the use of probiotics might assist in relieving histamine intolerance. 

Well, we all wish it was this straightforward. It is because not all bacteria are the same. Some strains of bacteria have genes in their chromosomal apparatus that encode histamine, while others don’t. Some may even have the ability to degrade the histamine produced in the human body. 

So, how does one know whether probiotics can be taken as a natural addition to your diet if you are histamine intolerant? Don’t worry; we have got you covered in the next question. 

Which strains of bacteria produce histamine? 

According to optibac probiotics, bacteria used to ferment food such as yogurt should be avoided. Lactobacillus casei and Lactobacillus bulgaricus are the two such strains that are most commonly used in fermented products. However, it’s worthy to note that not all strains within these bacterial species produce histamines. 

Importantly, a bacterial strain called Lactobacillus paracasei CASEI 431®, a clinically tested strain, doesn’t produce histamine. The abovementioned strain belongs to a species called Paracasei, not to be confused with Casei.

Which strains of bacteria don’t produce histamine? 

Several strains of bacteria don’t produce histamine and can therefore be used by people with histamine intolerance. It’s even mentioned in articles that some of these strains might be useful in reducing the allergic symptoms caused by elevated histamine levels. 

Strains such as Lactobacillus rhamnosus, Bifidobacterium infantis, Bifidobacterium longum, Lactobacillus Plantarum, and possibly Lactobacillus reuteri do not appear to produce histamine. 

Nonetheless, one should note that every human differs in certain aspects. What works for some might not be for you. Instead, you might suffer from some non-appealing side effects as well. Thus, you need to figure out what works best for you.  

Why is DS-01 Daily Synbiotic by SEED the Premium Probiotics to be used?

Probiotics offered by SEED are beneficial in almost every aspect of your body. SEED provides the best probiotic formula laden with multiple bacterial strains, whether your dermatological health or your cardiovascular system, to your gastrointestinal tract. 

Histamine intolerance and the associated consequences of this illness is predominantly related to your Gut. These can be managed with SEED’s 37.0 Billion AFU. It assists in your digestive health as well as your gut immunity. 

Probiotics offered by SEED are thoroughly tested and ensure that it doesn’t cause any adverse side effects. With its prebiotic capsule, one can have a more competent method of combating this disease. 

However, seed provides a premium-based formulation to its customers. Thus the product helps regulate the overall function of the human body instead of focusing on one single system.